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spr741 spr741  (Spero Inc)

 
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    Spero Inc spr741 spr741
    Spr741 Spr741, supplied by Spero Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/spr741/spr741/pm41724364-139-0-6
    Average 86 stars, based on 1 article reviews
    spr741 spr741 - by Bioz Stars, 2026-09
    86/100 stars

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    other:

    Article Title: 10-K
    Article Snippet: In addition to the license grant with respect to SPR206, the Company, through its wholly owned subsidiary, Spero Potentiator, Inc., a Delaware corporation, granted Everest a 12-month exclusive option to negotiate with it for an exclusive license to develop, manufacture and commercialize SPR741 in the Territory.

    Article Title: 10-Q
    Article Snippet: In addition to the license grant with respect to SPR206, the Company, through its wholly owned subsidiary, Spero Potentiator, Inc., a Delaware corporation, granted Everest a 12-month exclusive option to negotiate with it for an exclusive license to develop, manufacture and commercialize SPR741 in the Everest Territory.

    Northern Blot:

    Article Title: A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli .
    Article Snippet: .. We gratefully acknowledge Spero Therapeutics and Northern Antibiotics for providing samples of SPR741. ..

    Article Title: A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli
    Article Snippet: CHIR-090 , Sigma-Aldrich , Cat#SML3092. .. SPR741 , Spero Therapeutics and Northern Antibiotics , N/A. .. Diaminopimelic acid (DAP) , Fisher Scientific , Cat#AAB2239103.

    Adjuvant:

    Article Title: Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens.
    Article Snippet: The rapid increase in antimicrobial resistance (AMR) projects a “global emergency” and necessitates a need to discover alternative resources for combating drug-resistant pathogens or “superbugs.” One of the key themes in “One Health Concept” is based on the fact that the interconnected network of humans, the environment, and animal habitats majorly contribute to the rapid selection and spread of AMR.. Moreover, the injudicious and overuse of antibiotics in healthcare, the environment, and associated disciplines, further aggravates the concern.. The prevalence and persistence of AMR contribute to the global economic burden and are constantly witnessing an upsurge due to fewer therapeutic options, rising mortality statistics, and expensive healthcare.



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    Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with <t>SPR741</t> (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.
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    Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with SPR741 (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.

    Journal: iScience

    Article Title: A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli .

    doi: 10.1016/j.isci.2024.110894

    Figure Lengend Snippet: Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with SPR741 (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.

    Article Snippet: Bacterial and virus strains Refer to Data S7 This Work N/A Chemicals, peptides, and recombinant proteins Anhydrotetracycline Sigma-Aldrich Cat#37919 Spectinomycin Sigma-Aldrich Cat#S4014 Kanamycin Sigma-Aldrich Cat#60615 LOLCDE-in-1 MedChem Express Cat#HY-130839 Chloramphenicol Sigma-Aldrich Cat#C0378 CHIR-090 Sigma-Aldrich Cat#SML3092 SPR741 Spero Therapeutics and Northern Antibiotics N/A Diaminopimelic acid (DAP) Fisher Scientific Cat#AAB2239103 MOPS-minimal media TekNova Cat#M2101

    Techniques: Activity Assay, In Vitro