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spr741 spr741  (Spero Inc)

 
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    Spero Inc spr741 spr741
    Spr741 Spr741, supplied by Spero Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/spr741 spr741/product/Spero Inc
    Average 86 stars, based on 1 article reviews
    spr741 spr741 - by Bioz Stars, 2026-05
    86/100 stars

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    Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with <t>SPR741</t> (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.
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    Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with <t>SPR741</t> (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.
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    Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with SPR741 (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.

    Journal: iScience

    Article Title: A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli .

    doi: 10.1016/j.isci.2024.110894

    Figure Lengend Snippet: Figure 5. Whole-cell activity of MAC-0452936 analogs correlated with in vitro Lgt activity (A) Antibacterial activity (MICs) of MAC-0452936 (1) and synthetic analogs 2–7 against E. coli DtolC-pore and E. coli BW25113 with SPR741 (8 mg/mL) compared with their inhibitory activity (IC50s) in vitro against Lgt purified using either DDM- or amphipol lipid matrices. (B) Correlation of whole-cell MICs to in vitro Lgt IC50 values for seven analogs visualized in a scatterplot. For both DDM-Lgt and Amphipol-Lgt, each point in the scatterplot represents a different analog. A simple linear regression was used to determine the R2-correlation for both DDM-Lgt and Amphipol-Lgt.

    Article Snippet: Bacterial and virus strains Refer to Data S7 This Work N/A Chemicals, peptides, and recombinant proteins Anhydrotetracycline Sigma-Aldrich Cat#37919 Spectinomycin Sigma-Aldrich Cat#S4014 Kanamycin Sigma-Aldrich Cat#60615 LOLCDE-in-1 MedChem Express Cat#HY-130839 Chloramphenicol Sigma-Aldrich Cat#C0378 CHIR-090 Sigma-Aldrich Cat#SML3092 SPR741 Spero Therapeutics and Northern Antibiotics N/A Diaminopimelic acid (DAP) Fisher Scientific Cat#AAB2239103 MOPS-minimal media TekNova Cat#M2101

    Techniques: Activity Assay, In Vitro